2022年1月26日の新型コロナ等ウイルス不活化に新展開！ 【緑茶カテキン EGCｇ】の水溶液中での高濃度安定化に株式会社 HPG が成功 新型コロナ・インフルエンザ・SARS ウイルス不活化 九州保健福祉大学 薬学部長による検証結果の技術発表による報道が各メディアから一斉にリリースされました。

また、2月15日には海外にも以下の内容でリリースが配信されました。

HPG: New Breakthrough in Virus Inactivation with Green Tea Catechin (EGCg)

Epigallocatechin gallate (EGCg), a type of catechin contained in green tea, is a natural ingredient that is expected to have an antiviral effect, and its inactivating effect on viruses has been verified and published both in Japan and overseas. However, the major disadvantage of EGCg is that it lacks storage stability due to its strong antioxidant effect, which causes severe oxidative deterioration.

HPG Co., Ltd. (Chuo-ku, Tokyo) has successfully developed a water-soluble formulation technology of highly concentrated catechin EGCg with excellent storage stability and has started to apply for a patent as the world's first processing technology to stabilize the product at a high concentration in aqueous solution.

The new formulation overcomes this problem by stabilizing a high concentration in water and prevents the virus from entering cells by binding to viral proteins against various viruses that repeatedly mutate, such as influenza and novel coronaviruses.

It is stabilized at a high concentration of 10,000 ppm, and the concentration can be easily adjusted by dilution. All components are edible food additives and can be taken by people of all ages for oral care.

In addition, there is almost no damage to the original taste, aroma, or color of existing products due to astringency, bitterness, or discoloration peculiar to catechin EGCg, and the product can be used in a variety of fields.

Since it is highly effective against bacteria as well as viruses, it can be used as a substitute for hand alcohol products in the kitchen, food handling, and as a preventive measure against not only human but also bird and pig flu.

Inactivation effect of the component on various influenza viruses

This component inhibited the adsorption of virus particles to cells or the entry process against four influenza A and B virus strains. In vitro plaque reduction assay was performed using MDCK (Madin-Darby canine kidney) cells and It has been proved that epigallocatechin gallate (EGCg), a green tea catechin, has an antiviral effect by inhibiting the adsorption of epigallocatechin gallate to cells during the virus replication process.

Inactivation effect of the component on the novel coronavirus and SARS virus

It has been confirmed that EGCg at a low concentration of 10 ppm has a certain inhibitory effect on human coronavirus (HCoV)-229E, which is a close relative of SARS-CoV-2 and causes cold symptoms in humans, through the synergistic effects of direct inactivation and adsorption inhibition.